Publications

 

BioRxiv

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1. Chandrasekar I, Varghese CN, Ashokkumar P, Uppaluri S, Bhat R, Sekhar A. Tannic acid fortifies extracellular matrix against dicarbonyl stress. bioRxiv 2026.02.12.705672; doi: https://doi.org/10.64898/2026.02.12.705672

2. Banerjee M, Mishra S, Vinukumar G, Pandhari M, Sarvothama M, Parimala D, Korlimarla A, Srinath B, Bhat R. Breast cancer cell migration is potentiated by associated fibroblasts through a laminin-511-Integrin α6β1-transduced Arp2/3 localization. bioRxiv 2025.08.10.669320; doi: https://doi.org/10.1101/2025.08.10.669320

3. Banerjee M, Pandhari M, Mishra S, Vidhipriya K, Bhat R. A PKM2-YAP reciprocal repartitioning modulates invasion of breast cancer cells. bioRxiv 2025.07.10.664113; doi: https://doi.org/10.1101/2025.07.10.664113

4. Samanta B, Sen P, Bhat R. C2-α-dicarbonyls selectively impair morphodynamic interactions between cells and extracellular matrix. bioRxiv 2025.07.04.663109; doi: https://doi.org/10.1101/2025.07.04.663109

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2026

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1. Goutham S, Gopikrishnan A, Ashok G, Venas N, Harshavardhan BV, Radhakrishnan S, Jolly MK, Bhat R. Fibronectin and E-cadherin regulate unique invasive traits of drug-resistant ovarian cancer cells. npj Syst Biol Appl (2026). https://doi.org/10.1038/s41540-026-00777-1

2. Bose A, Bopanna Y, Shetty P, Sharma K, Mathew JKK, Mishra V, Bannerjee S, Ramani H, Pulimood AB, Bhat R, Shenoy AR, Visweswariah SS. Therapeutic zinc targets dysregulated GC-C signaling and restores ileal defects in a preclinical model of familial diarrheal disease. Am J Physiol Gastrointest Liver Physiol. 2026;331(2):G125-G139. doi: 10.1152/ajpgi.00049.2026.

3. Asthana S, Bhat AD, Mahadevan G, Kothegala L, Negi S, Yadav S, Sudhakaran A, Roy A, Makwana M, Patel R, Rao B H, George CE, Gayen S, Shukla S, Jhunjhunwala S, Sen P, Kaur P, Bhat R, Saini DK; Longevity India Team; Collaborators. The BHARAT study: a multi-modal, multi-omics investigation of aging signatures in the Indian population. Aging (Albany NY). 2026 Apr 24;18(1):380-396.

4. Pal M, Mukherjee S, Yadav P, Ahmed N, Hegde P, G K, Bhat R, Saini DK, Peddi S, Dasgupta D, Ghosh A. Magnetic Nanostructures Inside Cells: A Versatile Platform for Cellular Sensing, Manipulation, and Fabrication. Small. 2026 Apr;22(21):e12144.

5. Raunekar V, Saha SK, Sharma N, Dutta S, Sarkar M, Rani H, Deshpande N, Mohanty SS, Gopikrishnan A, Bhardhwaj K, Mishra S, Rangarajan A, Bhat R, Mahadevan V, Sen S. Glucose deprivation induces AMPK-dependent α-actinin-4 expression to sustain energy efficient non-proteolytic migration. J Cell Sci. 2026 27: jcs.264040. doi: 10.1242/jcs.264040.

6. Mishra S, Vidhipriya K, Gopikrishnan A, Mishra S, Hari PS, Korlimarla A, Prasanna CVS, Sen P, Bhat R. Glycation Driven Impairment of Cytoskeletal Homoeostasis and Viability Disables Glyoxalase-Low Mesothelia From Resisting Cancer Colonization. J Cell Physiol. 2026;241(1):e70123. doi: 10.1002/jcp.70123.

7. Prasanna CVS, Jolly MK, Bhat R. Dependence of mesenchymally transitioned tumor niche fitness on cell-cell and cell-matrix adhesions. Biophys J. doi:10.1016/j.bpj.2026.01.002.

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2025

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1. Saravanan Y, Valotteau C, Rico F, Bhat R. Length and time scales bridge poroelasticity and tissue architecture. J Biosci. 2025;50:79.

2. Sarkar P, Naha A, Hussain S, Manattayil JK, P S H, Korlimarla A, Vadaparty A, Raghunathan V, Kumar R, Bhat R. Downregulation of Decorin in ovarian cancer cells and colonization microenvironment drives progression. Biointerphases. 2025 1;20(5):051009. doi: 10.1116/6.0004725.

3. Kumar N, Samanta B, Km J, Raghunathan V, Sen P, Bhat R. Demonstration of Enhancement of Tumor Intravasation by Dicarbonyl Stress Using a Microfluidic Organ-on-chip. Small. 2025 Jan 2:e2405998.

4. Newman SA, Benítez M, Bhat R, Glimm T, Kumar KV, Nanjundiah V, Nicholson DJ, Sarkar S. Agency in the evolutionary transition to multicellularity. The Quarterly Review of Biology. 2025 Jun 1;100(2):83-118.

5. Dutt T, Langthasa J, Umesh M, Mishra S, Bothra S, Vidhipriya K, Vadaparty A, Sen P, Bhat R. Rheological transition driven by matrix makes cancer spheroids resilient under confinement. Life Sci Alliance. 2025 Mar 27;8(6):e202402601.

6. ​Mukherjee S, Ahmed N, Vasantha Ramachandran R, Bhat R, Kumar Saini D, Ghosh A. Anisotropy, topography and non-newtonian properties of cellular interiors probed by helical magnetic nanobots. J Microbio Robot. 2025;21(1):6.

7. Goswami S, Mukherjee S, Ahmed N, Sreepadmanabh M, Bhattacharjee T, Bhat R, Saini D, Ghosh A. Frequency-Chirped Actuation of Chiral Magnetic Microbots for Viscosity Mapping in Heterogenous Media: From Model Fluids to Living Cells. ACS Nano. 2025 Oct 8. doi: 10.1021/acsnano.5c09448.

8. Das A, Bhat R, Jolly MK. Fractal Measures as Predictors of Histopathological Complexity in Breast Carcinoma Mammograms. Phys Biol. 2025 Oct 3. doi: 10.1088/1478-3975/ae0f6e.

9. Sreepadmanabh M, Ganesh M, Langthasa J, Bhat R, Bhattacharjee T. Distinct Chemical Cues Reprogram Cellular and Multicellular Phenotypes in Ovarian Cancer Spheroids. Small. 2025 Sep 16:e06120. doi: 10.1002/smll.202506120.

10. Behera J, Laha SS, Dasgupta D, Goswami S, Mukherjee S, Jaiswar A, Modak P, Banerjee M, Ramachandran RV, Morozov KI, Leshansky AM, Bhat R, Saini DK, Ghosh A. Stable and Highly Steerable Magnetic Nanorobots Demonstrate Therapeutical Functionality in Crowded Biological Media. ACS Nano. 2025 13;19(18):17785-17795. 

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2024

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1. Suresh M, Bhat R. Ovarian cancer cells exhibit diverse migration strategies on stiff collagenous substrata. Biophys J. 2024;123(22):4009-4021.

2. Prasanna CVS, Jolly MK, Bhat R. Spatial heterogeneity in tumor adhesion qualifies collective cell invasion. Biophys J. 2024;123(12):1635-1647.

3. Prasad H, Mandal S, Mathew JKK, Cherukunnath A, Duddu AS, Banerjee M, Ramani H, Bhat R, Jolly MK, Visweswariah SS. An endosomal acid-regulatory feedback system rewires cytosolic cAMP metabolism and drives tumour progression. Mol Cancer Res. 2024 MCR-23-0606.

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​2023

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1. Thapa, B.V., Banerjee, M., Glimm, T. et al. The senescent mesothelial matrix accentuates colonization by ovarian cancer cells. Cell. Mol. Life Sci. 81, 2 (2024). https://doi.org/10.1007/s00018-023-05017-x

2. Lathia R, Nagpal S, Modak CD, Mishra S, Sharma D, Reddy BS, Nukala P, Bhat R, Sen P. Tunable encapsulation of sessile droplets with solid and liquid shells. Nat Commun. 2023 Oct 13;14(1):6445.

3. Arora, G, Banerjee, M, Langthasa, J, Bhat, R, Chatterjee, S, Targeting metabolic fluxes reverts metastatic transitions in ovarian cancer, iScience, 2023 doi: https:// doi.org/10.1016/j.isci.2023.108081.

4. Glimm T, Kaźmierczak B, Newman SA, Bhat R. A two-galectin network establishes mesenchymal condensation phenotype in limb development. Math Biosci. 2023 5;365:109054. 

5. Sreepadmanabh M, Ganesh M, Bhat R, Bhattacharjee T. Jammed microgel growth medium prepared by flash-solidification of agarose for 3D cell culture and 3D bioprinting. Biomed Mater. 2023 18;18(4).

6. Naik NN, et al, Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022. Altern. Lab. Anim. 2023 51(4):263-288. doi: 10.1177/02611929231180428. 

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2022

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1. Langthasa J, Mishra S, U Monica, Kalal R, Bhat R Mutations in a set of ancient matrisomal glycoprotein genes across neoplasia predispose to disruption of morphogenetic transduction. Comp Sys Oncol. 2022.

2. Jyothsna KM, Lal AS, Prosad A, Sarkar P, Kim H, Bhat R, Raghunathan V. (2022). Sub-diffraction Second Harmonic Generation Microscopy using Particle Swarm Optimized Phase Mask. Frontiers in Optics 2022 10.1364/FIO.2022.JTu4A.65.

3. Ramachandran RV, Barman A, Modak P, Bhat R, Ghosh A, Saini DK. How safe are magnetic nanomotors: From cells to animals. Biomater Adv. 2022 140:213048.

4. Pally D, Goutham S, Bhat R. Extracellular matrix as a driver for intratumoral heterogeneity. Phys Biol. 2022 19(4).

5. Pally D, Banerjee M, Hussain S, Kumar RV, Petersson A, Rosendal E, Gunnarsson L, Peterson K, Leffler H, Nilsson UJ, Bhat R. Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix. ACS Chem Biol. 2022 17(6):1376-1386.

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2021

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1. Newman SA, Bhat R, Glimm T. Spatial waves and temporal oscillations in vertebrate limb development. Biosystems. 2021 5;208:104502.

2. Langthasa J, Sarkar P, Narayanan S, Bhagat R, Vadaparty A, Bhat R*. Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids. Life Sci Alliance. 2021 Aug 10;4(10):e202000942.

3. Ramachandran RV, Bhat R, Kumar Saini D, Ghosh A. Theragnostic nanomotors: Successes and upcoming challenges. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 25:e1736.

4. Pally D and Bhat R* N-terminal tail prolines of Gal-3 mediate its oligomerization/phase separation (2021) Proc Nat Acad Sci USA 118(25): e2107023118.

5. Pramanik D, Jolly MK*, Bhat R* Matrix adhesion and remodeling diversifies modes of breast cancer invasion across spatial scales (2021) J Theor Biol 110733. 

6. Rastogi N, Seth P, Bhat R* and Sen P* Vortex chip incorporating an orthogonal turn for size-based isolation of circulating cells (2021) Anal Chim Acta 1159: 338423.

7. Kumawat B and Bhat R* An interplay of resource availability, population size and mutation rate potentiates the evolution of metabolic signaling (2021) BMC Ecology and Evolution 21(1):52.

8. Jyothsna K M, Sarkar P, Jha KK, Lal Krishna A S, Raghunathan V*, Bhat R*. A biphasic response of polymerized Type 1 collagen architectures to dermatan sulfate (2021) J Biomed Mat Res Part A 1–11.

9. Pally D, Pramanik D, Hussain S, Verma S, Srinivas A, Kumar RV, Bhat R*. ST6GAL1-mediated heterogeneity in sialic acid levels potentiates invasion of breast cancer epithelia (2021) ACS Centr Sci 7(1):110-125.

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2020

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1. Dasgupta D, Pally D, Saini DK, Bhat R*, Ghosh A*. Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments. Angew Chem Int Ed Engl. (2020) 59(52):23690-23696.

2. Goutham S, Kumari I, Pally D, Singh A, Ghosh S, Akhter Y, Bhat R* (2020) Mutually exclusive locales for N-linked glycans and disorder in human glycoproteins. Sci Rep 10(1): 6040.

3. Pal M, Dasgupta D, Somalwar N, Reshma VR, Tiwari M, Pally D, Narayana SM, Katke A, Jayshree RS, Bhat R*, Saini DK*, Ghosh A* (2020) Helical Nanobots as Mechanical Probes of Intra- and Extracellular Environments. J Phys Cond Matt 32: 224001.

4. Singh V, Bhat R*. (2020) Proteoglycan desulfation: a critical step in oncogenesis? Front Biosci (Landmark Ed) 25:760-780.

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​2019

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1. Singh V, Jha KK, Jyothsna KM, Kumar RV, Raghunathan V, Bhat R*. (2019) Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix. J Clin Med. 8(10). pii: E1562.

2. Jha KK, Sarkar P, Biswas R, Bhat R*, Raghunathan V*. (2019) A Spatiotemporal analysis using second harmonic generation reveals enhancement of Type I Collagen polymerization by dermatan sulfate glycosaminoglycans. Proc. SPIE 11076, Advances in Microscopic Imaging II, 110761G.

3. Pally D, Pramanik D, Bhat R* (2019) An Interplay Between Reaction-Diffusion and Cell-Matrix Adhesion Regulates Multiscale Invasion in Early Breast Carcinomatosis. Front. Physiol Biophys 10:790.

4. Balakrishnan A, Koppaka D, Anand A, Deb B, Grenci G, Viasnoff V, Thompson EW, Gowda H, Bhat R, Rangarajan A, Thiery JP, Govind Babu K, Kumar P*. (2019) Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival. Sci Rep. 28;9(1):7933.

5. Hamant O*, Bhat R, Nanjundiah V, Newman SA. (2019) Does resource availability help determine the evolutionary route to multicellularity? Evol Dev. doi:10.1111/ede.12287.

6. Bhat R*, Glimm T, Linde-Medina M, Cui C, Newman SA. (2019) Synchronization of Hes1oscillations coordinate and refine condensation formation and patterning of the avian limb skeleton. Mech Dev. S0925-4773(18)30126-6.

7. Gera S, Kumar SS, Swamy SN, Bhagat R, Vadaparty A, Gawari R, Bhat R*, Dighe RR* (2019) Follicle Stimulating Hormone Is an Autocrine Regulator of the Ovarian Cancer Metastatic Niche Through Notch Signaling. J Endocr Soc. 3(2):340-357.

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2018

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1. Pal M, Somalwar N, Singh A, Bhat R, Eswarappa S, Saini DK*, Ghosh A* (2018) Manoeuvrability of Magnetic Nanomotors Inside Living Cells Adv Materials 30(22):e1800429.

2. Newman SA*, Glimm T, Bhat R (2018) The vertebrate limb: An evolving complex of self-organizing systems. Prog Biophys Mol Biol S0079-6107(17)30285-7.

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2017

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1. Stewart TA, Bhat R and Newman SA* (2017) The evolutionary origin of digit patterning Evo Devo 10.1186/s13227-017-0084-8.

2. Bhat R* and Pally D (2017) Complexity: the organizing principle at the interface of biological (dis)order J. Gen. 96(3):431-444.

3. Yadavalli S, Jayaram S, Manda SS, Madugundu AK, Nayakanti DS, Tuan TZ, Bhat R, Rangarajan A, Chatterjee A, Gowda H, Thiery JP*, and Kumar P* (2017) Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells Sci Rep. 6;7:43710.

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2016

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1. Bhat R*, Belardi B, Mori H, Kuo P, Tam A, Hines WC, Le Q-T, Bertozzi CR*, and Bissell MJ* (2016) Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis Proc. Nat. Acad. Sci. USA 113(33): E4820-7.

2. Mori H, Bhat R, Bruni-Cardoso A, Chen EI, Jorgen EM, Koutinho K, Louie K, Bowen BB, Inman JL, Tecca V, Lee SJ, Becker-Weimann S, Northen T, Seiki M, Borowsky AD, Auer M and Bissell MJ*. (2016) New Insight into the Role of MMP-14 in Metabolic Balance Peer J  4: e2142.

3. Bhat R*, Chakraborty M, Glimm T, Stewart T and Newman SA (2016) Deep phylogenomics of a tandem-repeat galectin regulating appendicular skeletal pattern formation BMC Evol. Biol 16(1): 162.

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Before joining IISc

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2015

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1. Lee SE, Chen Q, Bhat R, Petkiewicz S, Smith JM, Ferry VE, Correia AL, Alivisatos AP, Bissell MJ*. (2015) Reversible Aptamer-Au Plasmon Rulers for Secreted Single Molecules. Nano Lett. 15(7): 4564-70.

2. Gomes AM, Bhat R, Correia AL, Mott JD, Ilan N, Vlodavsky I, Pavão MS, Bissell M*. (2015) Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14. J Cell Biochem. 116: 1668-79.

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2014

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1. Bhat R*, Chakraborty M, Mian IS and Newman SA. (2014) Structural divergence in vertebrate phylogeny of a duplicated prototype galectin. Gen Biol Evol. 6(10): 2721-30.

2. Chuong C-M, Bhat R, Widelitz R and Bissell MJ. (2014) Snapshot: Branching Morphogenesis. Cell 158(5): 1212-1212.e1.

3. Bhat R* and Bissell MJ. (2014) Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype. WIREs Dev Biol. 3, 147-163.

4. Bhat R (2014). Understanding Complexity through pattern languages in biological and manmade architectures. Int J Architect Res. 8:8-19.

5. Glimm T, Bhat R and Newman SA. (2014) Modeling the morphodynamic galectin patterning network of the developing avian limb skeleton. J Theor Biol. 346:86-108.

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2012

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1. Mori H, Borowsky AD, Bhat R, Ghajar CM, Seiki M, Bissell MJ. (2012) LS-TAFI a new technique for analysis of microanatomy in whole mount tissues. Am J Pathol. 180:2249-56.

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2011​

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1. Bhat R, Lerea KM, Peng H, Kaltner H, Gabius HJ, Newman SA. (2011). A regulatory network of two galectins mediates the earliest steps of avian limb skeletal morphogenesis. BMC Dev Biol. 11, 6.

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2009

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1. Bhat R and Newman SA. (2009). Snakes and ladders: the ups and downs of animal segmentation. J Biosci. 34:163-6.

2. Newman SA and Bhat R. (2009) Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form. Int J Dev Biol. 53:693-705.

3. Newman SA, Bhat R and Mezentseva NV. (2009). Cell state switching factors and dynamical patterning modules: complementary mediators of plasticity in development and evolution. J Biosci. 34(4):553-72.

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2008

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1. Newman SA and Bhat R. (2008). Dynamical patterning modules: physico-genetic determinants of morphological development and evolution. Phys Biol. 5:15008.

2. Newman SA and Bhat R. (2008). Activator-Inhibitor mechanisms of vertebrate limb pattern formation. Birth Defects Res C Embryo Today 81:305-19.

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2007

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1. Newman SA and Bhat R. (2007). Genes and proteins: Dogmas in decline. J Biosci. 32:1041.

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Book chapter

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1. Newman SA, Bhat R. (2011). Lamarck's dangerous idea. In: "Transformations of Lamarckism: from subtle fluids to molecular biology" (S. Gissis, E. Jablonka, Eds.), pp. 157-169. MIT Press, Cambridge, Mass.

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