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Publications

 

BioRxiv

 

1. Dicarbonyl stress enhances tumor intravasation Nilesh Kumar, Bidita Samanta, Jyothsna K M, Varun Raghunathan, Prosenjit Sen, Ramray Bhat bioRxiv 2024.07.03.601810; doi: https://doi.org/10.1101/2024.07.03.601810

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2. Dicarbonyl stress debilitates mesothelial defense against metastasizing ovarian cancer Satyarthi Mishra, Kottpalli Vidhipriya, Anchita Gopikrishnan, Sudiksha Mishra, CVSPrasanna, Prosenjit Sen, Ramray Bhat bioRxiv 2024.06.18.599500; doi: https://doi.org/10.1101/2024.06.18.599500

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3. Rheological transition driven by matrix makes cancer spheroids resilient under confinement Tavishi Dutt, Jimpi Langthasa, U Monica, Satyarthi Mishra, Siddharth Bothra, Annapurna Vadaparty, Prosenjit Sen, Ramray Bhat bioRxiv 2022.02.09.479678; doi: https://doi.org/10.1101/2022.02.09.479678

 

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2024

  1. Prasanna CVS, Jolly MK, Bhat R Spatial heterogeneity in tumor adhesion qualifies collective cell invasion doi: https://doi.org/10.1101/2023.10.05.559967 accepted, Biophys J. 2024

  2. Prasad H, Mandal S, Mathew JKK, Cherukunnath A, Duddu AS, Banerjee M, Ramani H, Bhat R, Jolly MK, Visweswariah SS. An endosomal acid-regulatory feedback system rewires cytosolic cAMP metabolism and drives tumour progression. Mol Cancer Res. 2024 MCR-23-0606.

 

​2023

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  1. Thapa, B.V., Banerjee, M., Glimm, T. et al. The senescent mesothelial matrix accentuates colonization by ovarian cancer cells. Cell. Mol. Life Sci. 81, 2 (2024). https://doi.org/10.1007/s00018-023-05017-x

  2. Arora, G, Banerjee, M, Langthasa, J, Bhat, R, Chatterjee, S, Targeting metabolic fluxes reverts metastatic transitions in ovarian cancer, iScience, 2023 doi: https:// doi.org/10.1016/j.isci.2023.108081.

  3. Glimm T, Kaźmierczak B, Newman SA, Bhat R. A two-galectin network establishes mesenchymal condensation phenotype in limb development. Math Biosci. 2023 5;365:109054. 

  4. Sreepadmanabh M, Ganesh M, Bhat R, Bhattacharjee T. Jammed microgel growth medium prepared by flash-solidification of agarose for 3D cell culture and 3D bioprinting. Biomed Mater. 2023 18;18(4).

  5. Naik NN, et al, Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022. Altern. Lab. Anim. 2023 51(4):263-288. doi: 10.1177/02611929231180428. 

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2022

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  1. Langthasa J, Mishra S, U Monica, Kalal R, Bhat R Mutations in a set of ancient matrisomal glycoprotein genes across neoplasia predispose to disruption of morphogenetic transduction. Comp Sys Oncol. 2022.

  2. Jyothsna KM, Lal AS, Prosad A, Sarkar P, Kim H, Bhat R, Raghunathan V. (2022). Sub-diffraction Second Harmonic Generation Microscopy using Particle Swarm Optimized Phase Mask. Frontiers in Optics 2022 10.1364/FIO.2022.JTu4A.65.

  3. Ramachandran RV, Barman A, Modak P, Bhat R, Ghosh A, Saini DK. How safe are magnetic nanomotors: From cells to animals. Biomater Adv. 2022 140:213048.

  4. Pally D, Goutham S, Bhat R. Extracellular matrix as a driver for intratumoral heterogeneity. Phys Biol. 2022 19(4).

  5. Pally D, Banerjee M, Hussain S, Kumar RV, Petersson A, Rosendal E, Gunnarsson L, Peterson K, Leffler H, Nilsson UJ, Bhat R. Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix. ACS Chem Biol. 2022 17(6):1376-1386.

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2021

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  1. Newman SA, Bhat R, Glimm T. Spatial waves and temporal oscillations in vertebrate limb development. Biosystems. 2021 5;208:104502.

  2. Langthasa J, Sarkar P, Narayanan S, Bhagat R, Vadaparty A, Bhat R*. Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids. Life Sci Alliance. 2021 Aug 10;4(10):e202000942.

  3. Ramachandran RV, Bhat R, Kumar Saini D, Ghosh A. Theragnostic nanomotors: Successes and upcoming challenges. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 25:e1736.

  4. Pally D and Bhat R* N-terminal tail prolines of Gal-3 mediate its oligomerization/phase separation (2021) Proc Nat Acad Sci USA 118(25): e2107023118.

  5. Pramanik D, Jolly MK*, Bhat R* Matrix adhesion and remodeling diversifies modes of breast cancer invasion across spatial scales (2021) J Theor Biol 110733. 

  6. Rastogi N, Seth P, Bhat R* and Sen P* Vortex chip incorporating an orthogonal turn for size-based isolation of circulating cells (2021) Anal Chim Acta 1159: 338423.

  7. Kumawat B and Bhat R* An interplay of resource availability, population size and mutation rate potentiates the evolution of metabolic signaling (2021) BMC Ecology and Evolution 21(1):52.

  8. Jyothsna K M, Sarkar P, Jha KK, Lal Krishna A S, Raghunathan V*, Bhat R*. A biphasic response of polymerized Type 1 collagen architectures to dermatan sulfate (2021) J Biomed Mat Res Part A 1–11.

  9. Pally D, Pramanik D, Hussain S, Verma S, Srinivas A, Kumar RV, Bhat R*. ST6GAL1-mediated heterogeneity in sialic acid levels potentiates invasion of breast cancer epithelia (2021) ACS Centr Sci 7(1):110-125.

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2020

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  1. Dasgupta D, Pally D, Saini DK, Bhat R*, Ghosh A*. Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments. Angew Chem Int Ed Engl. (2020) 59(52):23690-23696.

  2. Goutham S, Kumari I, Pally D, Singh A, Ghosh S, Akhter Y, Bhat R* (2020) Mutually exclusive locales for N-linked glycans and disorder in human glycoproteins. Sci Rep 10(1): 6040.

  3. Pal M, Dasgupta D, Somalwar N, Reshma VR, Tiwari M, Pally D, Narayana SM, Katke A, Jayshree RS, Bhat R*, Saini DK*, Ghosh A* (2020) Helical Nanobots as Mechanical Probes of Intra- and Extracellular Environments. J Phys Cond Matt 32: 224001.

  4. Singh V, Bhat R*. (2020) Proteoglycan desulfation: a critical step in oncogenesis? Front Biosci (Landmark Ed) 25:760-780.

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2019

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  1. Singh V, Jha KK, Jyothsna KM, Kumar RV, Raghunathan V, Bhat R*. (2019) Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix. J Clin Med. 8(10). pii: E1562.

  2. Jha KK, Sarkar P, Biswas R, Bhat R*, Raghunathan V*. (2019) A Spatiotemporal analysis using second harmonic generation reveals enhancement of Type I Collagen polymerization by dermatan sulfate glycosaminoglycans. Proc. SPIE 11076, Advances in Microscopic Imaging II, 110761G.

  3. Pally D, Pramanik D, Bhat R* (2019) An Interplay Between Reaction-Diffusion and Cell-Matrix Adhesion Regulates Multiscale Invasion in Early Breast Carcinomatosis. Front. Physiol Biophys 10:790.

  4. Balakrishnan A, Koppaka D, Anand A, Deb B, Grenci G, Viasnoff V, Thompson EW, Gowda H, Bhat R, Rangarajan A, Thiery JP, Govind Babu K, Kumar P*. (2019) Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival. Sci Rep. 28;9(1):7933.

  5. Hamant O*, Bhat R, Nanjundiah V, Newman SA. (2019) Does resource availability help determine the evolutionary route to multicellularity? Evol Dev. doi:10.1111/ede.12287.

  6. Bhat R*, Glimm T, Linde-Medina M, Cui C, Newman SA. (2019) Synchronization of Hes1oscillations coordinate and refine condensation formation and patterning of the avian limb skeleton. Mech Dev. S0925-4773(18)30126-6.

  7. Gera S, Kumar SS, Swamy SN, Bhagat R, Vadaparty A, Gawari R, Bhat R*, Dighe RR* (2019) Follicle Stimulating Hormone Is an Autocrine Regulator of the Ovarian Cancer Metastatic Niche Through Notch Signaling. J Endocr Soc. 3(2):340-357.

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2018

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  1. Pal M, Somalwar N, Singh A, Bhat R, Eswarappa S, Saini DK*, Ghosh A* (2018) Manoeuvrability of Magnetic Nanomotors Inside Living Cells Adv Materials 30(22):e1800429.

  2. Newman SA*, Glimm T, Bhat R (2018) The vertebrate limb: An evolving complex of self-organizing systems. Prog Biophys Mol Biol S0079-6107(17)30285-7.

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2017

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  1. Stewart TA, Bhat R and Newman SA* (2017) The evolutionary origin of digit patterning Evo Devo 10.1186/s13227-017-0084-8.

  2. Bhat R* and Pally D (2017) Complexity: the organizing principle at the interface of biological (dis)order J. Gen. 96(3):431-444.

  3. Yadavalli S, Jayaram S, Manda SS, Madugundu AK, Nayakanti DS, Tuan TZ, Bhat R, Rangarajan A, Chatterjee A, Gowda H, Thiery JP*, and Kumar P* (2017) Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells Sci Rep. 6;7:43710.

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2016

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  1. Bhat R*, Belardi B, Mori H, Kuo P, Tam A, Hines WC, Le Q-T, Bertozzi CR*, and Bissell MJ* (2016) Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis Proc. Nat. Acad. Sci. USA 113(33): E4820-7.

  2. Mori H, Bhat R, Bruni-Cardoso A, Chen EI, Jorgen EM, Koutinho K, Louie K, Bowen BB, Inman JL, Tecca V, Lee SJ, Becker-Weimann S, Northen T, Seiki M, Borowsky AD, Auer M and Bissell MJ*. (2016) New Insight into the Role of MMP-14 in Metabolic Balance Peer J  4: e2142.

  3. Bhat R*, Chakraborty M, Glimm T, Stewart T and Newman SA (2016) Deep phylogenomics of a tandem-repeat galectin regulating appendicular skeletal pattern formation BMC Evol. Biol 16(1): 162.

Langthasa J, Sarkar P, Bhat R (2020) The glycobiology of ovarian cancer progression: phenotypic switches and microenvironmental influences. In: "Phenotypic Switching, Implications in Biology and Medicine (Jolly, Levine, Nanjundiah and Kulkarni, Eds) pp. 527-551. Springer, India. 

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